To effectively use Spring's @Cacheable with multiple cache layers like EhCache and Redis while ensuring synchronized eviction across all instances, configure separate cache managers for each layer and implement a custom CacheResolver to manage cache access. When a cache entry is evicted using @CacheEvict, ensure that both EhCache and Redis are cleared for that entry through manual eviction logic. To synchronize this eviction across distributed instances, leverage Redis Pub/Sub: when an entry is evicted in one instance, publish a message to a Redis channel that all other instances subscribe to, prompting them to evict the same key from their caches. This approach ensures consistency and coherence across your caching strategy.