You are attempting to read an Excel file in the xlsx format. openpyxl is your go-to module, not xlrd and here is why, straight from the xlrd github page:

• Please use openpyxl where you can...
• xlrd is a library for reading (...) Excel files in the historical .xls format. (...) For alternatives that read newer file formats, please see http://www.python-excel.org/

python-excel.org/ itself starts with openpyxl: The recommended package for reading and writing Excel 2010 files (ie: .xlsx)