Yes, WP-Ecommerce does work with LinkPoint, but you may need to use a third-party integration plugin or custom development to set it up properly. WP-Ecommerce has built-in payment gateways, but LinkPoint may require some additional configuration or a custom API to make it work seamlessly. It's worth checking with WP-Ecommerce support or browsing the forums for any plugins that could simplify this integration.