Manage references carefully: Ensure that there are no lingering references to Python objects when PythonEngine is shut down or reused. Explicitly release resources: Use PythonEngine.Exec("del variable_name") to explicitly delete variables and clean up before shutting down the engine. 5. Investigate the PythonNet Version PythonNet is actively developed, and certain versions of the library may have bugs that cause memory violations. Make sure you're using the latest stable version of PythonNet