driver=SQL+Server is no longer maintained.

Instead use ODBC Driver 17 for SQL Server or ODBC Driver 18 for SQL Server.

If using connectorx:

conn = (
    f"mssql://{username}:{quote_plus(password)}@{server}:{port}/{database}"
    "?driver=ODBC+Driver+18+for+SQL+Server&MultiSubnetFailover=Yes"
)