Short answer: Yes, it is possible to prevent screenshots of PDFs by using advanced DRM tools like VeryPDF DRM Protector https://drm.verypdf.com/online/ . This software blocks all known screen capture methods, including disabling the "Print Screen" key and preventing tools like SnagIt and the Windows Snipping Tool. It also adds dynamic watermarks with user-specific details to discourage unauthorized sharing and uses military-grade encryption to restrict access. These features make it ideal for protecting sensitive content, such as eBooks, from piracy while maintaining a seamless user experience.