I have the same problem using the newest version from today, 12.1.1. 12.1.0 works without problems.
It seems to be related to detecting the language of the page:
highcharts.js:8 Uncaught TypeError: Cannot read properties of null (reading 'closest')
at highcharts.js:8:898
at highcharts.js:8:1778
at highcharts.js:9:272787
at highcharts.js:8:324
at highcharts.js:8:329
This is this line in the highcharts code:
t.pageLang = t.doc?.body.closest("[lang]")?.lang,
Updating production code on a friday is risky.. and now just before the Christmas holidays.