Similarly to @chux's answer, I'm used to do something like this ;

#define MAX_SZ 10485760UL
#define BLOCK_SZ 64UL

#define DP_BUF_RSV_SIZE     (256 * 16 * BLOCK_SZ)
#define DP_BUF_UL_SIZE      (3072 * 16 * BLOCK_SZ)
#define DP_BUF_DL_SIZE      (4096 * 16 * BLOCK_SZ)
#define DP_BUF_COMMON_SIZE  (2048 * 16 * BLOCK_SZ)

#if ((DP_BUF_RSV_SIZE + DP_BUF_UL_SIZE + DP_BUF_DL_SIZE + DP_BUF_COMMON_SIZE) > MAX_SZ)
#error Too large

// Eventually
#elif ((DP_BUF_RSV_SIZE + DP_BUF_UL_SIZE + DP_BUF_DL_SIZE + DP_BUF_COMMON_SIZE) % BLOCK_SZ)
#error Not multiple of 64
#endif

So the program wouldn't compile if DP_BUF_RSV_SIZE + DP_BUF_UL_SIZE + DP_BUF_DL_SIZE + DP_BUF_COMMON_SIZE is superior to MAX_SZ, or if it ain't a multiple of 64.