This error is likely related to permissions and security settings on macOS not disk space. "Operation not permitted" error usually occurs when the debugger doesn't have the necessary permissions to attach to the process.

You should try these solutions:

Try resetting all simulator settings:

xcrun simctl erase all

Check your Privacy & Security settings:

• Go to System Preferences/Settings → Privacy & Security
• Look for Developer Tools section
• Ensure Xcode is allowed

Reset debugging permissions:

sudo security authorizationdb remove system.privilege.taskport
sudo security authorizationdb write system.privilege.taskport < /System/Library/Security/Privile­gedHelperTools/system.privilege.taskport.plist

Try running this command in Terminal:

csrutil status

If System Integrity Protection (SIP) is enabled, it might be interfering. However, I don't recommend disabling SIP unless absolutely necessary.

Check your signing settings in Xcode:

• Select your project in the navigator
• Select your target
• Go to "Signing & Capabilities"
• Ensure your team is selected and signing is valid

Try running Xcode as root (this is temporary for testing):

sudo xcode-select -s /Applications/Xcode.app/Contents/Developer
sudo xcodebuild -runFirstLaunch

If none of the above works, you should:

Restart Xcode

Restart your Mac

Reinstall Command Line Tools:

xcode-select --install

Try these solutions in order and if they still do not resolve the issue, then I would like to know which version of Xcode you’re using, version of macOS, and is this happening with all simulator devices or just specific ones?