TESTED on win 10 at least, the native api in absolutelly all the following api calls: ZwCreateKey ZwOpenKey ZwOpenKeyEx
When oring the ACCESS_MASK (i.e.the DesiredAccess) parameter with either: KEY_WOW64_64KEY or KEY_WOW64_32KEY as required, yields the expected result of accesing the correct key.
In other words, tha native api (at least in user mode, not yet tested in kernel mode) supports with no problem the redirection overrides