A tuple can store duplicate values, while a frozenset enforces uniqueness. Tuples allow element access by index, but frozensets do not support indexing or slicing. Frozensets support set operations like union, intersection, and difference, whereas tuples lack these. Additionally, a tuple's hashability depends on its elements (it must contain only hashable items), while a frozenset is always hashable since it contains only immutable elements. Lastly, tuples preserve insertion order (since Python 3.7+), while frozensets are unordered, meaning iteration order is not guaranteed.