I was wondering about the same thing recently but excel does not have such feature i.e. the header on a side and DataBodyRange spreading further away sideways from it. You can have headers in the first column and DataBodyRange to the right of it. This would still formally be a table with header at the top so some functionality would not be possible e.g. filtering or sorting on the row etc. So yes you can have it, sort of. You still have a named region with some features working as they would be expected to.