https://www.jrebel.com/jrebel/learn/faq#

Should JRebel be used in production environments?

We do not recommend using JRebel in a production environment.

JRebel is a development tool and therefore meant to be used only in a development environment. Keep in mind that for JRebel to work, some memory and performance overhead is added. In a production environment, additional overhead like that is not desirable.