The router address you're using (0xE592427A0AEce92De3Edee1F18E0157C05861564) is incorrect for Sepolia— that's the mainnet address for Uniswap V3's SwapRouter. On the Sepolia testnet, you should use the SwapRouter02 address at 0x3bFA4769FB09eefC5a80d6E87c3B9C650f7Ae48E instead.

In Remix, when the transaction simulates and fails, expand the error message—it often includes a specific revert reason (e.g., "INSUFFICIENT_LIQUIDITY" or "INVALID_POOL"). That can pinpoint if it's something beyond the router address.