A minor edit of solution by Mr. Lance E Sloan. This is direct, like str.join(), doesn't add a lot of text, or unnecesary conversions. Instead of "in" for a single key we just use ".issubset()" for a set of keys.

opts = {'foo': 1, 'zip': 2, 'zam': 3, 'bar': 4}

if {'foo', 'bar'}.issubset(opts):
    #do stuff