Pytesseract reinitializes tesseract component and class for each execution hence it is slower python wrapper for Tesseract. On The Other hand, TesserOCR can be initialize once for an image to run multiple executions, e.g if you have multiple detected regions and you want to extract text from each patch with precision you can initialize image once and run parallel executions. Therefore, IT is always better to Use TesserOCR. We have a detailed case studies on this topic PyTesseract Vs TesserOCR