I created Parall, a macOS utility that lets you run multiple independent instances of any app, including Qt Creator.

Each shortcut bundle made with Parall launches the target app in its own isolated environment - separate HOME directory, environment variables, and settings. That means you can open several Qt Creator instances at the same time, each with different projects, plugins, or configurations, and they won't interfere with each other.

It requires no Terminal commands or duplicated app folders - just create the shortcut and launch.

The app is available in the Mac App Store and approved by Apple.